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Z-DEVD-FMK

CAT: 0013-GTR19162799-07Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162799-07Size:25 mg
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Description
Z-DEVD-FMK is a specific caspase-3 inhibitor with IC50 of 18 uM; affects the survival and function of platelets in platelet concentrate during storage, blocks the geranylgeraniol-induced DNA fragmentation in human leukemia cells; abolishes the apoptosis, CPP32/Mch3alpha processing and the increase in CPP32-like protease activity induced by TGF-beta1 in rat hepatocytes. (In Vitro) :N27 cells are exposed to MPP+ in the absence or presence of 50 μM Z-DIPD-FMK or 100 μM Z-DEVD-FMK or 50 μM Z-LEHD-FMK and then caspase-9 and caspase-3 enzymatic activities are determined by enzymatic assay at 12 and 24 h following exposure, respectively. Exposure to 300 μM MPP+ for 24 h in N27 cells results in an approximately 2.5-fold increase in caspase-3 enzyme activity. MPP+-induced increases in caspase-3 enzyme activity are significantly blocked by 50 μM Z-DIPD-FMK, 100 μM Z-DEVD-FMK, and 50 μM Z-LEHD-FMK. (In Vivo) :Early Z-DEVD-FMK (160 ng) treatment improves motor and cognitive function after traumatic CNS injury induced by severe controlled cortical impact (CCI) in the mouse. Treatment with Z-DEVD-FMK (160 ng) significantly improves neurological outcome when compared with traumatized animals treated with DMSO vehicle (p<0.01) .
CAS Number
210344-95-9
Product Name Alternative
Z-DEVD-fmk | Z DEVD fmk | ZDEVDfmk
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 33.33 mg/mL
Smiles
O=C (OC) CC[C@H] (NC ([C@@H] (NC (OCC1=CC=CC=C1) =O) CC (OC) =O) =O) C (N[C@@H] (C (C) C) C (N[C@H] (C (CF) =O) CC (OC) =O) =O) =O
Molecular Formula
C30H41FN4O12
Molecular Weight
668.6646
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
L-Valinamide, N-[ (phenylmethoxy) carbonyl]-L-α-aspartyl-L-α-glutamyl-N-[ (1S) -3-fluoro-1- (2-methoxy-2-oxoethyl) -2-oxopropyl]-, 1,2-dimethyl ester

Chemical Information

Z-Devd-fmk

Z-DEVD-FMK is a tetrapeptide consisting of Fmoc-L-aspartic acid 4-methyl ester, methyl L-alpha-glutamic acid 5-methyl ester, L-valine and the fluoromethyl ketone derived from the 1-carboxy group of L-aspartic acid 4-methyl ester coupled in sequence. It is a specific, irreversible caspase-3 inhibitor that also shows potent inhibition of caspase-6, caspase-7, caspase-8, and caspase-10. It has a role as an EC 3.4.22.56 (caspase-3) inhibitor, a neuroprotective agent and an apoptosis inhibitor.

CAS Number210344-95-9
PubChem CID16760394
IUPAC Namemethyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-4-methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-5-oxopentanoate
Molecular FormulaC30H41FN4O12
Molecular Weight668.7
XLogP0.9
Topological Polar Surface Area222
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count13
Rotatable Bond Count23
Heavy Atom Count47
Formal Charge0
Complexity1110
SMILES
CC(C)[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](CCC(=O)OC)NC(=O)[C@H](CC(=O)OC)NC(=O)OCC1=CC=CC=C1
InChI
InChI=1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1
InChIKey
GBJVAVGBSGRRKN-JYEBCORGSA-N
Chemical Structure
2D Structure
2D structure of Z-Devd-fmk
CAS: 210344-95-9
CID: 16760394
Formula: C30H41FN4O12
MW: 668.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight668.7
XLogP30.9
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count13
Rotatable Bond Count23
Exact Mass668.27050092
Monoisotopic Mass668.27050092
Topological Polar Surface Area222 Ų
Heavy Atom Count47
Formal Charge0
Complexity1110
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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