LX-2343

CAT: 0013-GTR19162559-01Size: 200 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19162559-01Size:200 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

LX-2343 is an non-ATP competitive PI3K inhibitor that negatively regulates AKT/mTOR signaling, thus promoting autophagy and increasing Aβ clearance, also inhibits BACE1 enzymatic activity with IC50 of 11.43 uM; reduced Aβ production involving JNK/APPThr668 pathway inhibition, LX2343 (5-20 uM) dose-dependently decreases Aβ accumulation in HEK293-APPsw and CHO-APP cells, and promotes Aβ clearance in SH-SY5Y cells and primary astrocytes; significantly ameliorates cognitive deficits and markedly ameliorates the Aβ pathology in brains in APP/PS1 transgenic mice.

CAS Number

333745-53-2

Product Name Alternative

LX2343

Purity

>98% (HPLC)

Solubility

< 1 mg/ml refers to the product slightly soluble or insoluble

Smiles

C1=C (NC (CN (C2=CC (Cl) =CC=C2OC) S (C2=CC=CC=C2) (=O) =O) =O) C=C2OCOC2=C1

Molecular Formula

C22H19ClN2O6S

Molecular Weight

474.912

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

N- (1,3-benzodioxol-5-yl) -2-[5-chloro-2-methoxy (phenylsulfonyl) anilino]acetamide

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