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LX-4211

CAT: 0013-GTR19164072-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19164072-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent, selective SGLT2 inhibitor with IC50 of 14 nM for hSGLT2; exhibits excellent selectivity over hSGLT1 (IC50=19 uM) ; inhibits SGLT2 in vitro and urinary glucose reabsorption in vivo.Diabetes Phase 2 Clinical (In Vitro) :LX4211 enhanced urinary glucose excretion by inhibiting SGLT2-mediated renal glucose reabsorption; markedly and significantly improved multiple measures of glycemic control, including fasting plasma glucose, oral glucose tolerance, and HbA (1c) ; and significantly lowered serum triglycerides. LX4211 also mediated trends for lower weight, lower blood pressure, and higher glucagon-like peptide-1 levels. In a follow-up single-dose study in 12 patients with T2DM, LX4211 (300 mg) significantly increased glucagon-like peptide-1 and peptide YY levels relative to pretreatment values, probably by delaying SGLT1-mediated intestinal glucose absorption . LX4211-treated mice and SGLT1-/- mice also had increased GLP-1 AUC values, decreased glucose-dependent insulinotropic polypeptide (GIP) AUC values, and decreased blood glucose excursions during the 6 hours after a challenge with oral glucose alone.
CAS Number
1018899-04-1
Product Name Alternative
Sotagliflozin | LP-802034 | LX4211 | LX 4211
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O[C@@H] ([C@@H] ([C@H] ([C@H] (C1=CC=C (Cl) C (CC2=CC=C (OCC) C=C2) =C1) O3) O) O) [C@H]3SC
Molecular Formula
C21H25ClO5S
Molecular Weight
424.9382
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
β-L-Xylopyranoside, methyl 5-C-[4-chloro-3-[ (4-ethoxyphenyl) methyl]phenyl]-1-thio-, (5S) -

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A3567-25LX-4211
MBS5759515LX-4211 intermediate
A12680-25LX-4211 25mg
A12680-500LX-4211 500mg
A12680-10LX-4211 10mg
A12680-2LX-4211 2mg
A12680-100LX-4211 100mg
A12680-50LX-4211 50mg
A12680-5LX-4211 5mg
A12680-1LX-4211 1mg

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