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GSK547

CAT: 0013-GTR19163090-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163090-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK547 (RIP1i, GSK 547) is a highly selective and potent inhibitor of RIP1 kinase that robustly targets RIP1 in vivo; exhibited a 400-fold improvement in mouse pharmacokinetic oral exposure compared with GSK'963; reprogrammed TAMs toward an MHCIIhiTNFα+IFNγ+ immunogenic phenotype in a STAT1-dependent manner. RIP1 inhibition in TAMs resulted in cytotoxic T cell activation and T helper cell differentiation toward a mixed Th1/Th17 phenotype, leading to tumor immunity in mice and in organotypic models of human Pancreatic ductal adenocarcinoma (PDA) .
CAS Number
2226735-55-1
Product Name Alternative
RIP1i | GSK 547 | GSK-547
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 125 mg/mL 315.35 mM
Smiles
N#CC1=NC=NC (N2CCC (C (N3N=CC[C@H]3C4=CC (F) =CC (F) =C4) =O) CC2) =C1
Molecular Formula
C20H18F2N6O
Molecular Weight
396.402
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(S) -6- (4- (5- (3,5-difluorophenyl) -4,5-dihydro-1H-pyrazole-1-carbonyl) piperidin-1-yl) pyrimidine-4-carbonitrile

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HY-114492-01GSK547
T12666-01(Rac)-GSK547
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A19073-25GSK547 25mg
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A19073-5GSK547 5mg
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