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YM-201636

CAT: 0013-GTR19162339-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162339-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YM-201636 is a potent, selective PIKfyve inhibitor with IC50 of 33 nM, does not inhibits type Iiγ/Iα PtdInsP kinases even at 10 uM (p110α IC50=3.3 uM) ; shows insensitivity against yeast orthologue of PIKfyve, Fab1; significantly decreases the production of PtdIns (3,5) P2 by 80% in serum-starved NIH3T3 cells with no effect on serum-stimulated PKB Ser 473 phosphorylation at 0.8 uM; inhibits basal and insulin-activated 2-deoxyglucose uptake withIC50 of 54 nM; significantly reduces retroviruses budding from cells; blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells.
CAS Number
371942-69-7
Product Name Alternative
YM 201636 | YM201636
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 47 mg/mL
Smiles
O=C (C1=CC=C (N) N=C1) NC2=CC=CC (C3=NC (N4CCOCC4) =C (OC5=NC=CC=C56) C6=N3) =C2
Molecular Formula
C25H21N7O3
Molecular Weight
467.4793
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3-Pyridinecarboxamide, 6-amino-N-[3-[4- (4-morpholinyl) pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-

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