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Nadolol

CAT: 0013-GTR19162237-02Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162237-02Size:200 mg
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Description
A non-selective beta-adrenergic antagonist with a long half-life, used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension. Nadolol is also used for MIGRAINE DISORDERS and for tremor. (In Vitro) :In human embryonic kidney 293 cells, (-) -Epigallocatechin gallate (EGCG) competitively inhibits OATP1A2-mediated uptake of Nadolol with a Ki value of 19.4 μM. With respect to Nadolol, the Km for OATP1A2 is 84 μM. (In Vivo) :In male OF1 mice bearing B16F10 tumor cells, blocking the neuroendocrine response through the administration of Nadolol (20 mg/kg) results in fewer and smaller pulmonary metastatic foci in subjects exposed to acute social stress.
CAS Number
42200-33-9
Product Name Alternative
Nadolol, Corgard, Solgol, SQ-11725, Anabet
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Soluble in Water
Smiles
O[C@@H]1CC2=C (C (OCC (O) CNC (C) (C) C) =CC=C2) C[C@@H]1O
Molecular Formula
C17H27NO4
Molecular Weight
309.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(2R,3S) -5-[3- (tert-butylamino) -2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol

Chemical Information

Nadolol

Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure. Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adverse effects. Nadolol was granted FDA approval on 10 December 1979.

CAS Number42200-33-9
PubChem CID39147
IUPAC Name(2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol
Molecular FormulaC17H27NO4
Molecular Weight309.4
XLogP0.7
Topological Polar Surface Area82
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count22
Formal Charge0
Complexity344
SMILES
CC(C)(C)NCC(COC1=CC=CC2=C1C[C@@H]([C@@H](C2)O)O)O
InChI
InChI=1S/C17H27NO4/c1-17(2,3)18-9-12(19)10-22-16-6-4-5-11-7-14(20)15(21)8-13(11)16/h4-6,12,14-15,18-21H,7-10H2,1-3H3/t12?,14-,15+/m1/s1
InChIKey
VWPOSFSPZNDTMJ-UCWKZMIHSA-N
Chemical Structure
2D Structure
2D structure of Nadolol
CAS: 42200-33-9
CID: 39147
Formula: C17H27NO4
MW: 309.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight309.4
XLogP30.7
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass309.19400834
Monoisotopic Mass309.19400834
Topological Polar Surface Area82 Ų
Heavy Atom Count22
Formal Charge0
Complexity344
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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