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Nadolol

CAT: 0013-GTR19162237-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162237-01Size:100 mg
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Description
A non-selective beta-adrenergic antagonist with a long half-life, used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension. Nadolol is also used for MIGRAINE DISORDERS and for tremor. (In Vitro) :In human embryonic kidney 293 cells, (-) -Epigallocatechin gallate (EGCG) competitively inhibits OATP1A2-mediated uptake of Nadolol with a Ki value of 19.4 μM. With respect to Nadolol, the Km for OATP1A2 is 84 μM. (In Vivo) :In male OF1 mice bearing B16F10 tumor cells, blocking the neuroendocrine response through the administration of Nadolol (20 mg/kg) results in fewer and smaller pulmonary metastatic foci in subjects exposed to acute social stress.
CAS Number
42200-33-9
Product Name Alternative
Nadolol, Corgard, Solgol, SQ-11725, Anabet
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Soluble in Water
Smiles
O[C@@H]1CC2=C (C (OCC (O) CNC (C) (C) C) =CC=C2) C[C@@H]1O
Molecular Formula
C17H27NO4
Molecular Weight
309.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(2R,3S) -5-[3- (tert-butylamino) -2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol

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