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Nadolol

CAT: 0931-T1203Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T1203Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
42200-33-9
Target
Adrenergic Receptor
Related Pathways
GPCR/G Protein, Neuroscience
Purity
0.9992
Bioactivity
Nadolol is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. Nadolol competitively blocks beta-1 adrenergic receptors located in the heart and vascular smooth muscle, inhibiting the activities of the catecholamines epinephrine and norepinephrine and producing negative inotropic and chronotropic effects. This agent exhibits antiarrhythmic activity via the impairment of atrioventricular (AV) node conduction and a corresponding reduction in sinus rate. In the kidney, inhibition of the beta-2 receptor within the juxtaglomerular apparatus results in the inhibition of renin production and a subsequent reduction in angiotensin II and aldosterone levels, thus inhibiting angiotensin II-dependent vasoconstriction and aldosterone-dependent water retention.
Smiles
CC(C)(C)NCC(O)COc1cccc2CC(O)C(O)Cc12
Molecular Formula
C17H27NO4
Molecular Weight
309.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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