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Pranoprofen

CAT: 0013-GTR19162152-07Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162152-07Size:200 mg
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Description
Pranoprofen is a PGE2 inhibitor with IC50 of 7.5 μM. (In Vitro) :Pranoprofen (pretreatment for 1 h; 1 mM) has an inhibitory effect against ER stress-induced GRP78 and CHOP expression in glial cells.Pranoprofen (5-25 μM; 24 h) dose-dependently enhances Dicer expression. Additionally, Pranoprofen at 5 μM enhances H2O2 (800 μM) -induced Dicer expression in FHC cells. (In Vivo) :Pranoprofen (oral administration; 4 mg/kg/16 mg/kg; 9 days) rescues Dicer expression in inflamed colon tissues, alleviates colitis and prevents colitis-associated colon cancers in C57BL/6 mice.Dicer is a key component of the RNA interference pathway and is essential for the biogenesis of miRNAs and siRNAs.
CAS Number
52549-17-4
Product Name Alternative
Pyranoprofen | Y 8004
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 6 mg/mL (23.5 mM) ; DMSO: 51 mg/mL (199.78 mM)
Smiles
CC (C1=CC (CC2=CC=CN=C2O3) =C3C=C1) C (O) =O
Molecular Formula
C15H13NO3
Molecular Weight
255.28
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (5H-Chromeno[2,3-b]pyridin-7-yl) propanoic acid

Chemical Information

Pranoprofen

Pranoprofen is a pyridochromene.

CAS Number52549-17-4
PubChem CID4888
IUPAC Name2-(5H-chromeno[2,3-b]pyridin-7-yl)propanoic acid
Molecular FormulaC15H13NO3
Molecular Weight255.27
XLogP2.7
Topological Polar Surface Area59.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count19
Formal Charge0
Complexity346
SMILES
CC(C1=CC2=C(C=C1)OC3=C(C2)C=CC=N3)C(=O)O
InChI
InChI=1S/C15H13NO3/c1-9(15(17)18)10-4-5-13-12(7-10)8-11-3-2-6-16-14(11)19-13/h2-7,9H,8H2,1H3,(H,17,18)
InChIKey
TVQZAMVBTVNYLA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pranoprofen
CAS: 52549-17-4
CID: 4888
Formula: C15H13NO3
MW: 255.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight255.27
XLogP32.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass255.08954328
Monoisotopic Mass255.08954328
Topological Polar Surface Area59.4 Ų
Heavy Atom Count19
Formal Charge0
Complexity346
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
FM27121-01Pranoprofen
166007Pranoprofen-d3
RG-A261883-01Pranoprofen Impurity A
A11641-500Pranoprofen 500mg
A11641-50Pranoprofen 50mg
HY-B0336R-01Pranoprofen (Standard)

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