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Pranoprofen

CAT: 0804-HY-B0336-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0336-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pranoprofen is a non-steroidal anti-inflammatory agent (NSAID) for the research of keratitis or other ophthalmology diseases. Pranoprofen inhibit COX-1 and COX-2 enzymes, thus blocking arachidonic acid converted to eicosanoids and reducing prostaglandins synthesis[1][2].
CAS Number
52549-17-4
UNSPSC
12352005
Hazard Statement
H301
Target
Apoptosis; COX; PGE synthase
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Pranoprofen.html
Purity
98.65
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC(C(O)=O)C1=CC2=C(C=C1)OC3=NC=CC=C3C2
Molecular Formula
C15H13NO3
Molecular Weight
255.27
Precautions
H301
References & Citations
[1]Toru Hosoi, et al. Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells. Neurochem Int. 2009 Jan;54 (1) :1-6.|[2]Minting Chen, et al. The Therapeutic Effects and Possible Mechanism of Pranoprofen in Mouse Model of Corneal Alkali Burns. J Ophthalmol. 2020 Apr 6;2020:7485912.|[3]Xiaoli Wu, et al. Rescuing Dicer expression in inflamed colon tissues alleviates colitis and prevents colitis-associated tumorigenesis. Theranostics. 2020 Apr 27;10 (13) :5749-5762.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
COX-1; COX-2

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