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Pentostatin

CAT: 0013-GTR19162097-02Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162097-02Size:500 mg
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Description
Pentostatin is an extremely potent (Ki = 2.5 pM), irreversible inhibitor of adenosine deaminase. This compound is effective against a variety of cancer cell lines. (In Vitro) :In ECP and Pentostatin (CI-825; Deoxycoformycin; 4 mg/m2, i.v.) treatment, all dogs develop granulocytopenia with <500 granulocytes/μL from day 4. Thrombocytopenia (<20,000 platelets/μL) occurs from day 7 after HCT with nadirs of 3000 to 14000 platelets/μL. Pentostatin (2 mg/kg) in combination with cordycepin (2 mg/kg) is 100% effective in the T. evansi-infected mice. There is an increase in levels of some biochemical parameters, especially on liver enzymes, which are accompanied by histological lesions in the liver and kidneys. Pentostatin individually has no curative effect on infected groups.
CAS Number
53910-25-1
Product Name Alternative
CI 825 | CL 67310465 | DCF | Deoxycoformycin | NSC 218321 | NSC 247520
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Water: 100 mM; DMSO: 75 mM
Smiles
O[C@H]1C2=C (N ([C@H]3O[C@H] (CO) [C@@H] (O) C3) C=N2) N=CNC1
Molecular Formula
C11H16N4O4
Molecular Weight
268.27
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(R) -3- ((2S,4S,5R) -4-hydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl) -3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol

Chemical Information

Pentostatin

Pentostatin can cause developmental toxicity according to state or federal government labeling requirements.

CAS Number53910-25-1
PubChem CID439693
IUPAC Name(8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol
Molecular FormulaC11H16N4O4
Molecular Weight268.27
XLogP-2.1
Topological Polar Surface Area112
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Heavy Atom Count19
Formal Charge0
Complexity356
SMILES
C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2NC=NC[C@H]3O)CO)O
InChI
InChI=1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1
InChIKey
FPVKHBSQESCIEP-JQCXWYLXSA-N
Chemical Structure
2D Structure
2D structure of Pentostatin
CAS: 53910-25-1
CID: 439693
Formula: C11H16N4O4
MW: 268.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight268.27
XLogP3-2.1
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass268.11715500
Monoisotopic Mass268.11715500
Topological Polar Surface Area112 Ų
Heavy Atom Count19
Formal Charge0
Complexity356
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
P076-1MGPentostatin

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