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Pentostatin

CAT: 0013-GTR19162097-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162097-01Size:200 mg
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Description
Pentostatin is an extremely potent (Ki = 2.5 pM), irreversible inhibitor of adenosine deaminase. This compound is effective against a variety of cancer cell lines. (In Vitro) :In ECP and Pentostatin (CI-825; Deoxycoformycin; 4 mg/m2, i.v.) treatment, all dogs develop granulocytopenia with <500 granulocytes/μL from day 4. Thrombocytopenia (<20,000 platelets/μL) occurs from day 7 after HCT with nadirs of 3000 to 14000 platelets/μL. Pentostatin (2 mg/kg) in combination with cordycepin (2 mg/kg) is 100% effective in the T. evansi-infected mice. There is an increase in levels of some biochemical parameters, especially on liver enzymes, which are accompanied by histological lesions in the liver and kidneys. Pentostatin individually has no curative effect on infected groups.
CAS Number
53910-25-1
Product Name Alternative
CI 825 | CL 67310465 | DCF | Deoxycoformycin | NSC 218321 | NSC 247520
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Water: 100 mM; DMSO: 75 mM
Smiles
O[C@H]1C2=C (N ([C@H]3O[C@H] (CO) [C@@H] (O) C3) C=N2) N=CNC1
Molecular Formula
C11H16N4O4
Molecular Weight
268.27
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(R) -3- ((2S,4S,5R) -4-hydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl) -3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol

Alternative Products

CatalogName
T4006-01Pentostatin

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