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VGX-1027

CAT: 0013-GTR19161115-04Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161115-04Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VGX-1027 (GIT27) is an isoxazole compound that exhibits various immunomodulatory properties; reduce the secretion of IL-1beta, TNF-alpha and IL-10 from purified murine macrophages. (In Vitro) :VGX-1027 (37.5, 75, 150, 300 μM; for 24 h) does not affect the viability of tumor cells, including the three malignant rodent cell lines (mouse fibrosarcoma L929, rat astrocytoma C6, and mouse melanoma B16) and the four human cell lines (adenocarcinoma HeLa, breast carcinoma BT20, colon carcinoma LS174, and glioblastoma U251) . (In Vivo) :VGX-1027 (10, 20 mg/kg of i.p. for 12 day or 100 mg/kg of p.o. for 11 day) successfully counteractes the development of destructive insulitis and hyperglycemia.VGX-1027 (25 mg/kg; ip; single dose) counteracts the uveitis-inducing effect of LPS in eight-week-old male Lewis rats (180-220 g) .
CAS Number
6501-72-0
Product Name Alternative
VGX-1027
Purity
>98% (HPLC)
Solubility
Ethanol: 41 mg/mL (199.79 mM) ; DMSO: 41 mg/mL (199.79 mM)
Smiles
O=C (O) CC1CC (C2=CC=CC=C2) =NO1
Molecular Formula
C11H11NO3
Molecular Weight
205.21
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (3-phenyl-4,5-dihydroisoxazol-5-yl) acetic acid

Chemical Information

Zenuzolac
CAS Number6501-72-0
PubChem CID10798271
IUPAC Name2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid
Molecular FormulaC11H11NO3
Molecular Weight205.21
XLogP1.3
Topological Polar Surface Area58.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count15
Formal Charge0
Complexity269
SMILES
C1C(ON=C1C2=CC=CC=C2)CC(=O)O
InChI
InChI=1S/C11H11NO3/c13-11(14)7-9-6-10(12-15-9)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,13,14)
InChIKey
MUFJHYRCIHHATF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Zenuzolac
CAS: 6501-72-0
CID: 10798271
Formula: C11H11NO3
MW: 205.21
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight205.21
XLogP31.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass205.07389321
Monoisotopic Mass205.07389321
Topological Polar Surface Area58.9 Ų
Heavy Atom Count15
Formal Charge0
Complexity269
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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A12548-100VGX-1027 100mg
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