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VGX-1027

CAT: 0013-GTR19161115-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161115-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VGX-1027 (GIT27) is an isoxazole compound that exhibits various immunomodulatory properties; reduce the secretion of IL-1beta, TNF-alpha and IL-10 from purified murine macrophages. (In Vitro) :VGX-1027 (37.5, 75, 150, 300 μM; for 24 h) does not affect the viability of tumor cells, including the three malignant rodent cell lines (mouse fibrosarcoma L929, rat astrocytoma C6, and mouse melanoma B16) and the four human cell lines (adenocarcinoma HeLa, breast carcinoma BT20, colon carcinoma LS174, and glioblastoma U251) . (In Vivo) :VGX-1027 (10, 20 mg/kg of i.p. for 12 day or 100 mg/kg of p.o. for 11 day) successfully counteractes the development of destructive insulitis and hyperglycemia.VGX-1027 (25 mg/kg; ip; single dose) counteracts the uveitis-inducing effect of LPS in eight-week-old male Lewis rats (180-220 g) .
CAS Number
6501-72-0
Product Name Alternative
VGX-1027
Purity
>98% (HPLC)
Solubility
Ethanol: 41 mg/mL (199.79 mM) ; DMSO: 41 mg/mL (199.79 mM)
Smiles
O=C (O) CC1CC (C2=CC=CC=C2) =NO1
Molecular Formula
C11H11NO3
Molecular Weight
205.21
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (3-phenyl-4,5-dihydroisoxazol-5-yl) acetic acid

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Alternative Products

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C17972-50mgVGX-1027
A12548-50VGX-1027 50mg
A12548-100VGX-1027 100mg
A12548-10VGX-1027 10mg
A12548-5VGX-1027 5mg
MBS130549-01VGX-1027(GIT27)
A12548-25VGX-1027 25mg
A12548-10mM-DVGX-1027 10mM * 1mL in DMSO
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