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PX-478

CAT: 0013-GTR19161006-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161006-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent, selective inhibitor of HIF-1α and HIF-1 transcription factor activity; inhibits the hypoxia-induced increase in HIF-1α protein in PC-3, MCF-7, HT-29 and Panc-1 with IC50 of 3.9, 4.0, 19.4 and 10.1 nM, respectively; suppresses HIF-1α levels in HT-29 human colon cancer xenografts and inhibits the expression of HIF-1 target genes including VEGFR and the glucose transporter-1.Blood Cancer Phase 1 Discontinued.
CAS Number
685898-44-6
Product Name Alternative
PX478 | PX 478
Purity
>98% (HPLC)
Solubility
H2O: ≥ 35 mg/mL
Smiles
Cl.Cl.N[C@@H] (CC1=CC=C (C=C1) [N+] ([O-]) (CCCl) CCCl) C (O) =O |r, c:5,7, t:3|
Molecular Formula
C13H20Cl4N2O3
Molecular Weight
394.1215
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
L-Phenylalanine, 4-[bis (2-chloroethyl) oxidoamino]-, (Hydrochloride) (1:2)

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