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Canrenone

CAT: 0013-GTR19160621-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160621-01Size:500 mg
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Description
A synthetic pregnadiene compound with anti-aldosterone activity. (In Vitro) :Canrenone inhibits the production of eortieosterone, 18-hydroxydesoxyeortieosterone, 18-hydroxycorticosterone and aldosterone in a dose-dependent manner. Canrenone dose-dependently reduces platelet-derived growth factor–induced cell proliferation and motility. Canrenone inhibits the activity of the Na+/H+ exchanger 1 induced by platelet-derived growth factor. (In Vivo) :Canrenone is the principal active metabolite of Spironolactone in the rat only for a limited period. During chronic treatment a difference developed between the effect of Spironolactone and Canrenone on the RAAS indicating a decrease in the anti-mineralocorticoid activity of Canrenone and an increase in the efficacy of Spironolactone.
CAS Number
976-71-6
Product Name Alternative
Aldadiene | NSC 261713 | SC-9376 | SC-14266
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: > 10 mM
Smiles
O=C1CC[C@]2 (CO3) C4CC[C@]5 (C3=O) [C@] (O) (CCC (O) =O) CC[C@@]5 ([H]) [C@]4 ([H]) C=CC2=C1
Molecular Formula
C22H28O3
Molecular Weight
340.46
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3- ((8R,10S,13R,14S,17R) -17-hydroxy-3,18-dioxo-2,3,8,9,11,12,14,15,16,17-decahydro-1H-10,13- (methanooxymethano) cyclopenta[a]phenanthren-17-yl) propanoic acid

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