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Sertaconazole nitrate

CAT: 0013-GTR19160590-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160590-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sertaconazole nitrate is a topical broad-spectrum antifungal that is developed to provide an additional agent for the treatment of superficial cutaneous and mucosal infections. (In Vitro) :Sertaconazole nitrate (0.03-40 μg/mL; 24 h) inhibits 150 strains of yeasts which includes six Candida species with arithmetic mean MIC of 0.77 μg/mL.Sertaconazole nitrate (1 μg/mL; 5, 10, 30, 60 min) activates p38 MAP kinase in a time-dependent manner.Sertaconazole nitrate (1, 2 μg/mL; 6, 8, or 24 h) increases a twofold release of PGE2 via COX-2 in keratinocytes, which is dependent on p38 activation.Sertaconazole nitrate (10, 20, 30, 40 μM; 24 h) induces strong mitotic arrest by depolymerizing interphase and spindle microtubules, thereby inducing chromosome aggregation defects and causing anti-proliferation effect.Sertaconazole nitrate (20, 40 μM; 24 h) induces apoptosis through p53 pathway in HeLa cells.Sertaconazole nitrate (20, 30 μM; 24, 48, and 72 h) inhibits the migration of HeLa cells in a concentration-dependent manner.Sertaconazole nitrate (15, 30 μM; 24 h) induces autophagy in A549, H460 cells. (In Vivo) :Sertaconazole nitrate (1% (w/v) ; apply to the left ear, once) suppresses of TPA-induced ear edema CD-1 mice.
CAS Number
99592-39-9
Product Name Alternative
FI-7045
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO:100 mg/mL (199.68 mM) ; Ethanol:<1 mg/mL (<1 mM) ; Water:<1 mg/mL (<1 mM)
Smiles
O[N+] ([O-]) =O.ClC1=CC (Cl) =C (C=C1) C (CN1C=CN=C1) OCC1=CSC2=C1C=CC=C2Cl
Molecular Formula
C20H15Cl3N2OS·HNO3
Molecular Weight
500.78
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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Alternative Products

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B1831-5.1Sertaconazole nitrate
HY-B0736A-01Sertaconazole (nitrate)
HY-B0736AR-01Sertaconazole (nitrate) (Standard)
CS-T-52659Sertaconazole Nitrate EP Impurity A
RM-S052002-01Sertaconazole Nitrate EP Impurity B
RM-S052003-01Sertaconazole Nitrate EP Impurity C
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