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Sulconazole Nitrate

CAT: 0013-GTR19158710-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19158710-01Size:200 mg
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Description
Sulconazole Nitrate is the nitrate salt form of sulconazole, a synthetic imidazole derivative with the antifungal property. Sulconazole nitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and inhibition of the synthesis of ergosterol, an important component of the fungal cell membrane. Inhibition of ergosterol synthesis leads to a disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. In addition, sulconazole nitrate seems to interfere with the autolytic degradation of fungal DNA and RNA. (In Vitro) :Sulconazole mononitrate possesses a broad spectrum of antifungal activity, inhibiting the growth of dermatophytes, yeasts and various filamentous and dimorphic fungi at oncentrations below 5 mg/L in vitro. Sulconazole mononitrate has also demonstrated antibacterial activity in vitro, with MIC values below 12.5 mg/L, against several Staphylococcus species, Streptococcus faecalis and certain gram-positive anaerobes.
CAS Number
61318-91-0
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 125 mg/mL (271.29 mM)
Smiles
C1cc (ccc1CSC (Cn1ccnc1) c1c (cc (cc1) Cl) Cl) Cl.[N+] (=O) (O) [O-]
Molecular Formula
C18H15Cl3N2S·HNO3
Molecular Weight
460.76
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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