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AZ 3146

CAT: 0013-GTR19160549-02Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160549-02Size:500 mg
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Description
AZ3146 is a novel and potent Mps1 inhibitor, which was used to probe the role of Mps1's catalytic activity during mitosis. AZ3146 also inhibits FAK, JNK1, JNK2, KSP and Kit. In in vitro kinase assays, AZ3146 inhibited human Mps1Cat with an IC50 (50% inhibitory concentration) of ~35 nM. AZ3146 also efficiently inhibited autophosphorylation of full-length Mps1 immunoprecipitated from human cells.
CAS Number
1124329-14-1
Product Name Alternative
AZ3146 | AZ 3146 | AZ-3146
Purity
>98% (HPLC)
Solubility
DMSO : 11.75 mg/mL 25.96 mM
Smiles
COc1c (Nc2ncc3n (C) c (=O) n (C4CCCC4) c3n2) ccc (OC2CCN (C) CC2) c1
Molecular Formula
C24H32N6O3
Molecular Weight
452.55
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
9-cyclopentyl-2- (2-methoxy-4- (1-methylpiperidin-4-yloxy) phenylamino) -7-methyl-7H-purin-8 (9H) -one

Chemical Information

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
CAS Number1124329-14-1
PubChem CID56973724
IUPAC Name9-cyclopentyl-2-[2-methoxy-4-(1-methylpiperidin-4-yl)oxyanilino]-7-methylpurin-8-one
Molecular FormulaC24H32N6O3
Molecular Weight452.5
XLogP3.2
Topological Polar Surface Area83.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count33
Formal Charge0
Complexity669
SMILES
CN1CCC(CC1)OC2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCCC5)OC
InChI
InChI=1S/C24H32N6O3/c1-28-12-10-17(11-13-28)33-18-8-9-19(21(14-18)32-3)26-23-25-15-20-22(27-23)30(24(31)29(20)2)16-6-4-5-7-16/h8-9,14-17H,4-7,10-13H2,1-3H3,(H,25,26,27)
InChIKey
YUKWVHPTFRQHMF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
CAS: 1124329-14-1
CID: 56973724
Formula: C24H32N6O3
MW: 452.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight452.5
XLogP33.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass452.25358890
Monoisotopic Mass452.25358890
Topological Polar Surface Area83.1 Ų
Heavy Atom Count33
Formal Charge0
Complexity669
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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