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ETC-159

CAT: 0013-GTR19169997-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169997-01Size:5 mg
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Description
ETC-159 is a potent and orally bioavailable small molecule inhibitor of PORCN, demonstrating an IC50 of 2.9 nM in β-catenin pathway reporter assays. It is a valuable research tool for investigating Wnt/β-catenin signaling in various cancer models, both in vitro and in vivo.
CAS Number
1638250-96-0
Product Name Alternative
Beta-catenin, betacatenin, bcatenin, Inhibitor, ETC 159, ETC 1922159, ETC159, ETC-159, ETC1922159, ETC-1922159, inhibit, Porcupine, Porcn, Wnt, Wnt/b-catenin, Wnt/betacatenin, Wnt/β-catenin, βcatenin, β-catenin
Field of Research
Signal Transduction, Stem Cell & Developmental Biology
Purity
96.87% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.11 mM) ; DMSO:55 mg/mL (140.53 mM)
Smiles
Cn1c2ncn (CC (=O) Nc3ccc (nn3) -c3ccccc3) c2c (=O) n (C) c1=O
Molecular Formula
C19H17N7O3
Molecular Weight
391.38
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Etc-159

Porcupine Inhibitor ETC-159 is an orally bioavailable inhibitor of the membrane-bound O-acyltransferase (MBOAT) porcupine (PORCN), with potential antineoplastic activity. Upon oral administration, ETC-159 binds to and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational palmitoylation of Wnt ligands and inhibits their secretion. This prevents the activation of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in Wnt-driven tumors. Porcupine catalyzes the palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion. Wnt signaling is dysregulated in a variety of cancers.

CAS Number1638250-96-0
PubChem CID86280523
IUPAC Name2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(6-phenylpyridazin-3-yl)acetamide
Molecular FormulaC19H17N7O3
Molecular Weight391.4
XLogP0.5
Topological Polar Surface Area113
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count29
Formal Charge0
Complexity654
SMILES
CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(=O)NC3=NN=C(C=C3)C4=CC=CC=C4
InChI
InChI=1S/C19H17N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-20-17)10-15(27)21-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,21,23,27)
InChIKey
QTRXIFVSTWXRJJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Etc-159
CAS: 1638250-96-0
CID: 86280523
Formula: C19H17N7O3
MW: 391.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight391.4
XLogP30.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass391.13928743
Monoisotopic Mass391.13928743
Topological Polar Surface Area113 Ų
Heavy Atom Count29
Formal Charge0
Complexity654
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
HY-18988-01ETC-159

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