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VS-5584

CAT: 0013-GTR19160924-05Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160924-05Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VS-5584, also known as SB2343, is a potent and selective inhibitor of both phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor VS-5584 inhibits mTOR kinase and all class I PI3K isoforms. Consequently, this disrupts phosphorylation of substrates downstream of PI3K and mTOR and may result in apoptosis and growth inhibition in susceptible tumor cells. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy.
CAS Number
1246560-33-7
Product Name Alternative
VS5584 | VS 5584 | VS5584 | SB2343
Purity
>98% (HPLC)
Solubility
DMSO : 33.33 mg/mL. 94.04 mM
Smiles
CC (C) n1c (C) nc2c1nc (nc2c1cnc (N) nc1) N1CCOCC1
Molecular Formula
C17H22N8O
Molecular Weight
354.41
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5- (9-isopropyl-8-methyl-2-morpholino-9H-purin-6-yl) pyrimidin-2-amine

Chemical Information

Vs-5584

VS-5584 has been used in trials studying the treatment of Lymphoma, Metastatic Cancer, and Non Hematologic Cancers.

CAS Number1246560-33-7
PubChem CID46912230
IUPAC Name5-(8-methyl-2-morpholin-4-yl-9-propan-2-ylpurin-6-yl)pyrimidin-2-amine
Molecular FormulaC17H22N8O
Molecular Weight354.4
XLogP0.8
Topological Polar Surface Area108
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Heavy Atom Count26
Formal Charge0
Complexity466
SMILES
CC1=NC2=C(N=C(N=C2N1C(C)C)N3CCOCC3)C4=CN=C(N=C4)N
InChI
InChI=1S/C17H22N8O/c1-10(2)25-11(3)21-14-13(12-8-19-16(18)20-9-12)22-17(23-15(14)25)24-4-6-26-7-5-24/h8-10H,4-7H2,1-3H3,(H2,18,19,20)
InChIKey
QYBGBLQCOOISAR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Vs-5584
CAS: 1246560-33-7
CID: 46912230
Formula: C17H22N8O
MW: 354.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight354.4
XLogP30.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass354.19165736
Monoisotopic Mass354.19165736
Topological Polar Surface Area108 Ų
Heavy Atom Count26
Formal Charge0
Complexity466
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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