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VS 8

CAT: 0013-GTR19185515-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19185515-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VS 8 is a potent, orally bioavailable small molecule inhibitor targeting VEGFR-2. It demonstrates robust anti-angiogenic activity, induces cancer cell apoptosis and inhibits migration, and shows efficacy against cancer stem cells (CSCs) in preclinical research. Its activity has been investigated in both in vitro assays and in vivo tumor models.
CAS Number
2471865-38-8
Field of Research
Cardiovascular Research, Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction
Smiles
O (C=1C2=C (C (NC (NC3=CC (C (F) (F) F) =CC=C3) =O) =CC=C2) C=CC1) C4=CC=C (NC (C) =O) C=C4
Molecular Formula
C26H20F3N3O3
Molecular Weight
479.45
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-[4-[5-[[3-(trifluoromethyl)phenyl]carbamoylamino]naphthalen-1-yl]oxyphenyl]acetamide
CAS Number2471865-38-8
PubChem CID162653073
IUPAC NameN-[4-[5-[[3-(trifluoromethyl)phenyl]carbamoylamino]naphthalen-1-yl]oxyphenyl]acetamide
Molecular FormulaC26H20F3N3O3
Molecular Weight479.4
XLogP5.3
Topological Polar Surface Area79.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count35
Formal Charge0
Complexity726
SMILES
CC(=O)NC1=CC=C(C=C1)OC2=CC=CC3=C2C=CC=C3NC(=O)NC4=CC=CC(=C4)C(F)(F)F
InChI
InChI=1S/C26H20F3N3O3/c1-16(33)30-18-11-13-20(14-12-18)35-24-10-4-7-21-22(24)8-3-9-23(21)32-25(34)31-19-6-2-5-17(15-19)26(27,28)29/h2-15H,1H3,(H,30,33)(H2,31,32,34)
InChIKey
ZCMXAYQHMRJMHV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-[4-[5-[[3-(trifluoromethyl)phenyl]carbamoylamino]naphthalen-1-yl]oxyphenyl]acetamide
CAS: 2471865-38-8
CID: 162653073
Formula: C26H20F3N3O3
MW: 479.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight479.4
XLogP35.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass479.14567599
Monoisotopic Mass479.14567599
Topological Polar Surface Area79.5 Ų
Heavy Atom Count35
Formal Charge0
Complexity726
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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