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UNC2881

CAT: 0013-GTR19160498-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160498-01Size:200 mg
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Description
UNC2881 is a potent Mer kinase inhibitor. UNC2281 inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. Treatment with UNC2281 is also sufficient to block EGF-mediated stimulation of a chimeric receptor containing the intracellular domain of Mer fused to the extracellular domain of EGFR. In addition, UNC2881 potently inhibits collagen-induced platelet aggregation, suggesting that this class of inhibitors may have utility for prevention and/or treatment of pathologic thrombosis.
CAS Number
1493764-08-1
Product Name Alternative
UNC2881, UNC-2881, UNC 2881
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 44 mg/mL; 94.91 mM
Smiles
CCCCNc1ncc (c (N[C@@H]2CC[C@H] (CC2) O) n1) C (=O) NCc1ccc (n2ccnc2) cc1
Molecular Formula
C25H33N7O2
Molecular Weight
463.58
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (4- (1H-imidazol-1-yl) benzyl) -2- (butylamino) -4- (((1r,4r) -4-hydroxycyclohexyl) amino) pyrimidine-5-carboxamide

Chemical Information

2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide
CAS Number1493764-08-1
PubChem CID71721525
IUPAC Name2-(butylamino)-4-[(4-hydroxycyclohexyl)amino]-N-[(4-imidazol-1-ylphenyl)methyl]pyrimidine-5-carboxamide
Molecular FormulaC25H33N7O2
Molecular Weight463.6
XLogP3.8
Topological Polar Surface Area117
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count10
Heavy Atom Count34
Formal Charge0
Complexity608
SMILES
CCCCNC1=NC=C(C(=N1)NC2CCC(CC2)O)C(=O)NCC3=CC=C(C=C3)N4C=CN=C4
InChI
InChI=1S/C25H33N7O2/c1-2-3-12-27-25-29-16-22(23(31-25)30-19-6-10-21(33)11-7-19)24(34)28-15-18-4-8-20(9-5-18)32-14-13-26-17-32/h4-5,8-9,13-14,16-17,19,21,33H,2-3,6-7,10-12,15H2,1H3,(H,28,34)(H2,27,29,30,31)
InChIKey
NPVXOWLPOFYACO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide
CAS: 1493764-08-1
CID: 71721525
Formula: C25H33N7O2
MW: 463.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight463.6
XLogP33.8
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count10
Exact Mass463.26957332
Monoisotopic Mass463.26957332
Topological Polar Surface Area117 Ų
Heavy Atom Count34
Formal Charge0
Complexity608
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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