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AZD1981

CAT: 0013-GTR19160242-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160242-01Size:200 mg
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Description
AZD1981is an orally available selective CRTH or DP2 antagonist currently in clinical development for asthma. AZD1981 blocks functional responses in eosinophils, Th2 cells and basophils. AZD1981 displaced radio-labelled PGD2 from human recombinant DP2 with high potency (pIC50 = 8.4) . Binding was reversible, non-competitive and highly selective against a panel of more than 340 other enzymes and receptors, including DP1 (>1000-fold selective) . AZD1981 inhibited DP2 -mediated shape change and CD11b up-regulation in human eosinophils, shape change in basophils and chemotaxis of human eosinophils and Th2 cells with similar potency. AZD1981 exhibited good cross-species binding activity against mouse, rat, guinea pig, rabbit and dog DP2 . Evaluation in mouse, rat or rabbit cell systems was not possible as they did not respond to DP2 agonists. Agonist responses were seen in guinea pig and dog, and AZD1981 blocked DP2 -mediated eosinophil shape change. Such responses were more robust in the guinea pig, where AZD1981 also blocked DP2 -dependent eosinophil emigration from bone marrow.
CAS Number
802904-66-1
Product Name Alternative
AZD1981 | AZD-1981 | AZD 1981
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 31 mg/mL; 79.72 mM
Smiles
Cc1c (c2c (n1CC (=O) O) cccc2NC (=O) C) Sc1ccc (cc1) Cl
Molecular Formula
C19H17ClN2O3S
Molecular Weight
388.87
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (4-acetamido-3- ((4-chlorophenyl) thio) -2-methyl-1H-indol-1-yl) acetic acid

Chemical Information

Azd-1981

AZD1981 has been used in trials studying the treatment and basic science of Asthma, Postmenopausal, Pharmakokinetic, Asthma Patients, and Drug Interaction, among others.

CAS Number802904-66-1
PubChem CID11292191
IUPAC Name2-[4-acetamido-3-(4-chlorophenyl)sulfanyl-2-methylindol-1-yl]acetic acid
Molecular FormulaC19H17ClN2O3S
Molecular Weight388.9
XLogP4
Topological Polar Surface Area96.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count26
Formal Charge0
Complexity527
SMILES
CC1=C(C2=C(C=CC=C2N1CC(=O)O)NC(=O)C)SC3=CC=C(C=C3)Cl
InChI
InChI=1S/C19H17ClN2O3S/c1-11-19(26-14-8-6-13(20)7-9-14)18-15(21-12(2)23)4-3-5-16(18)22(11)10-17(24)25/h3-9H,10H2,1-2H3,(H,21,23)(H,24,25)
InChIKey
JWYIGNODXSRKGP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Azd-1981
CAS: 802904-66-1
CID: 11292191
Formula: C19H17ClN2O3S
MW: 388.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight388.9
XLogP34
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass388.0648413
Monoisotopic Mass388.0648413
Topological Polar Surface Area96.6 Ų
Heavy Atom Count26
Formal Charge0
Complexity527
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
510315AZD1981
A13186-10AZD1981 10mg
A13186-200AZD1981 200mg
A13186-100AZD1981 100mg
A13186-50AZD1981 50mg
A13186-5AZD1981 5mg
HY-15950R-01AZD1981 (Standard)
A13186-25AZD1981 25mg
A13186-10mM-DAZD1981 10mM * 1mL in DMSO

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