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AZD1283

CAT: 0013-GTR19172185-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19172185-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZD1283 is a potent and selective P2Y12 receptor antagonist with an IC50 of 11 nM, demonstrating effective antithrombotic activity and inhibition of ADP-induced platelet aggregation in vivo. It shows a favorable therapeutic index (≥10) by achieving efficacy at doses lower than those significantly increasing bleeding time, making it a useful research tool for cardiovascular and thrombosis studies.
CAS Number
919351-41-0
Product Name Alternative
Antiplatelet aggregation, antithrombotic, AZD 1283, AZD1283, AZD-1283, inhibit, P2YReceptor, P2Y12, P2Y Receptor, P2Y, Inhibitor, thromboembolic
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.29% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.25 mM) ; DMSO:22.5 mg/mL (47.82 mM)
Smiles
CCOC (=O) c1cc (C#N) c (nc1C) N1CCC (CC1) C (=O) NS (=O) (=O) Cc1ccccc1
Molecular Formula
C23H26N4O5S
Molecular Weight
470.54
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Azd-1283
CAS Number919351-41-0
PubChem CID23649325
IUPAC Nameethyl 6-[4-(benzylsulfonylcarbamoyl)piperidin-1-yl]-5-cyano-2-methylpyridine-3-carboxylate
Molecular FormulaC23H26N4O5S
Molecular Weight470.5
XLogP2.5
Topological Polar Surface Area138
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Heavy Atom Count33
Formal Charge0
Complexity835
SMILES
CCOC(=O)C1=C(N=C(C(=C1)C#N)N2CCC(CC2)C(=O)NS(=O)(=O)CC3=CC=CC=C3)C
InChI
InChI=1S/C23H26N4O5S/c1-3-32-23(29)20-13-19(14-24)21(25-16(20)2)27-11-9-18(10-12-27)22(28)26-33(30,31)15-17-7-5-4-6-8-17/h4-8,13,18H,3,9-12,15H2,1-2H3,(H,26,28)
InChIKey
NEMHKCNXXRQYRF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Azd-1283
CAS: 919351-41-0
CID: 23649325
Formula: C23H26N4O5S
MW: 470.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight470.5
XLogP32.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Exact Mass470.16239112
Monoisotopic Mass470.16239112
Topological Polar Surface Area138 Ų
Heavy Atom Count33
Formal Charge0
Complexity835
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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