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AZD1283

CAT: 0013-GTR19160182-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160182-01Size:1 g
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Description
AZD1283 is a potent antagonist of the P2Y12 receptor. In a modified Folts model in dog, both AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithrombotic ED50 values of 3.0 μg/kg/min. The doses that induced a larger than 3-fold increase in bleeding time were 33 μg/kg/min. Thus, the therapeutic index (TI) was ≥ 10. On the basis of these data, AZD1283 was progressed into human clinical trials as candidate drug.
CAS Number
919351-41-0
Product Name Alternative
AZD-1283 | AZD1283 | AZD 1283
Purity
>98% (HPLC)
Solubility
DMSO : 100 mg/mL. 212.52 mM; H2O : < 0.1 mg/mL
Smiles
CCOC (=O) c1c (nc (c (c1) C#N) N1CCC (CC1) C (=O) NS (=O) (=O) Cc1ccccc1) C
Molecular Formula
C23H26N4O5S
Molecular Weight
470.54
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Ethyl 6- (4- ((benzylsulfonyl) carbamoyl) piperidin-1-yl) -5-cyano-2-methylnicotinate.

Chemical Information

Azd-1283
CAS Number919351-41-0
PubChem CID23649325
IUPAC Nameethyl 6-[4-(benzylsulfonylcarbamoyl)piperidin-1-yl]-5-cyano-2-methylpyridine-3-carboxylate
Molecular FormulaC23H26N4O5S
Molecular Weight470.5
XLogP2.5
Topological Polar Surface Area138
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Heavy Atom Count33
Formal Charge0
Complexity835
SMILES
CCOC(=O)C1=C(N=C(C(=C1)C#N)N2CCC(CC2)C(=O)NS(=O)(=O)CC3=CC=CC=C3)C
InChI
InChI=1S/C23H26N4O5S/c1-3-32-23(29)20-13-19(14-24)21(25-16(20)2)27-11-9-18(10-12-27)22(28)26-33(30,31)15-17-7-5-4-6-8-17/h4-8,13,18H,3,9-12,15H2,1-2H3,(H,26,28)
InChIKey
NEMHKCNXXRQYRF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Azd-1283
CAS: 919351-41-0
CID: 23649325
Formula: C23H26N4O5S
MW: 470.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight470.5
XLogP32.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Exact Mass470.16239112
Monoisotopic Mass470.16239112
Topological Polar Surface Area138 Ų
Heavy Atom Count33
Formal Charge0
Complexity835
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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510259AZD1283
A15443-2AZD1283 2mg
A15443-1AZD1283 1mg
A15443-500AZD1283 500mg
A15443-100AZD1283 100mg
A15443-50AZD1283 50mg
A15443-25AZD1283 25mg
A15443-10AZD1283 10mg
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