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AZD1208

CAT: 0013-GTR19159761-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159761-06Size:100 mg
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Description
AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. Pan-PIM kinase inhibitor AZD1208 inhibits the activities of PIM1, PIM2 and PIM3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, thereby causing cell cycle arrest and inducing apoptosis in cells that overexpress PIMs. The growth inhibition of several leukemia cell lines by this agent is correlated with the expression levels of PIM1, which is the substrate of STAT transcription factors. PIM kinases are downstream effectors of many cytokine and growth factor signaling pathways and are upregulated in various malignancies.
CAS Number
1204144-28-4
Product Name Alternative
AZD1208 | AZD-1208
Purity
>98% (HPLC)
Solubility
DMSO : 28.5 mg/mL 75.10 mM
Smiles
C1 (c (cccc1/C=C/1\SC (=O) NC1=O) c1ccccc1) N1CCC[C@H] (C1) N
Molecular Formula
C21H21N3O2S
Molecular Weight
379.48
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5-[[2-[ (3R) -3-Aminopiperidin-1-yl]biphenyl-3-yl]methylidene]-1,3-thiazolidine-2,4-dione

Chemical Information

Azd-1208
CAS Number1204144-28-4
PubChem CID58423153
IUPAC Name(5Z)-5-[[2-[(3R)-3-aminopiperidin-1-yl]-3-phenylphenyl]methylidene]-1,3-thiazolidine-2,4-dione
Molecular FormulaC21H21N3O2S
Molecular Weight379.5
XLogP3.6
Topological Polar Surface Area101
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count27
Formal Charge0
Complexity602
SMILES
C1C[C@H](CN(C1)C2=C(C=CC=C2C3=CC=CC=C3)/C=C\4/C(=O)NC(=O)S4)N
InChI
InChI=1S/C21H21N3O2S/c22-16-9-5-11-24(13-16)19-15(12-18-20(25)23-21(26)27-18)8-4-10-17(19)14-6-2-1-3-7-14/h1-4,6-8,10,12,16H,5,9,11,13,22H2,(H,23,25,26)/b18-12-/t16-/m1/s1
InChIKey
MCUJKPPARUPFJM-UWCCDQBKSA-N
Chemical Structure
2D Structure
2D structure of Azd-1208
CAS: 1204144-28-4
CID: 58423153
Formula: C21H21N3O2S
MW: 379.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight379.5
XLogP33.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass379.13544809
Monoisotopic Mass379.13544809
Topological Polar Surface Area101 Ų
Heavy Atom Count27
Formal Charge0
Complexity602
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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