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Cornuside

CAT: 0013-GTR19159705-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19159705-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cornuside has immunomodulatory activity . Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. Cornuside can treat myocardial I/R and protect the liver from CCl4-induced acute hepatotoxicity, by reducing oxidative stress and suppressing inflammatory responses. Cornuside has anti-inflammatory activity by downregulations of iNOS and COX-2 due to NF-κB inhibition as well as the negative regulation of ERK1/2, p38, and JNK1/2 phosphorylations in RAW 264.7 cells. Cornuside has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca (2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties.
CAS Number
131189-57-6
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (184.34 mM)
Smiles
COC (=O) C1=COC (C (C1CCOC (=O) C2=CC (=C (C (=C2) O) O) O) C=C) OC3C (C (C (C (O3) CO) O) O) O
Molecular Formula
C24H30O14
Molecular Weight
542.49
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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