Products for Research Use Only
RegisterLogin

HTHQ

CAT: 0013-GTR19159607-08Size: 200 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19159607-08Size:200 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
HX-1171, also known as HTHQ, is a lipid peroxidation inhibitor potentially for the treatment of hepatic fibrosis. HTHQ and vitamin E attenuated interleukin-1beta-induced iNOS protein expression in cultured hepatocytes, the potency of HTHQ being 10-times higher than that of vitamin E. HTHQ may prevent tumor production induced by AP and NaNO2 more effectively than ascorbic acid. (In Vitro) :HTHQ (0-100 μM; 24 hours; PC12 cells) treatment increases cell viabilities in a dose-dependent manner.HTHQ (10 μM; 0.6-24 hours; PC12 cells) inhibits 3,4-L-Dihydroxyphenylalanine (L-DOPA) -induced phosphorylation of sustaines extracellular signal-regulated kinases (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK1/2) . HTHQ also normalizes L-DOPA-reduced Bcl-2-associated death protein (Bad) phosphorylation and Bcl-2-associated X protein (Bax) expression, promoting cell survival. (In Vivo) :HTHQ (50-200 mg/kg; oral administration; for 4 weeks; specific pathogen-free male Sprague Dawley rats) treatment significantly improves liver weight and serum chemistry level. HTHQ reduces hydroxyproline and malondialdehyde level in the liver. HTHQ treatment also reduces fibrotic septa. HTHQ administration shows reduced mRNA level of PDGF (Plateletderived growth factor), α-SMA (α-smooth muscle actin) and TGF-β (transforming growth factor-β) than DMN-induced hepetic fibrosis animals in the liver tissue.
CAS Number
148081-72-5
Product Name Alternative
HX-1171 | HX-1171 | HX-1171 | HTHQ
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 100 mg/mL; 423.10 mM
Smiles
CCCCCCOc1c (c (c (c (c1) C) O) C) C
Molecular Formula
C15H24O2
Molecular Weight
236.35
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4- (hexyloxy) -2,3,6-trimethylphenol

Chemical Information

Hthq

Hx 1171 is under investigation in clinical trial NCT01548391 (A Phase I Clinical Study Study of the Safety, Tolerability, and Pharmacokinetics of HX-1171 in Healthy Male Subjects).

CAS Number148081-72-5
PubChem CID119193
IUPAC Name4-hexoxy-2,3,6-trimethylphenol
Molecular FormulaC15H24O2
Molecular Weight236.35
XLogP4.4
Topological Polar Surface Area29.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count6
Heavy Atom Count17
Formal Charge0
Complexity205
SMILES
CCCCCCOC1=C(C(=C(C(=C1)C)O)C)C
InChI
InChI=1S/C15H24O2/c1-5-6-7-8-9-17-14-10-11(2)15(16)13(4)12(14)3/h10,16H,5-9H2,1-4H3
InChIKey
ATMNQRRJNBCQJO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Hthq
CAS: 148081-72-5
CID: 119193
Formula: C15H24O2
MW: 236.35
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight236.35
XLogP34.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count6
Exact Mass236.177630004
Monoisotopic Mass236.177630004
Topological Polar Surface Area29.5 Ų
Heavy Atom Count17
Formal Charge0
Complexity205
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR17954532HTH Antibody
GTR17969366Hth Antibody
GTR19174974-01HTH-01-015
GTR19200227-01HTH-01-091
GTR19218229-01HTH-02-006
GTR19162978-01HTH-01-015
GTR19221583-01HTH-01-091 TFA
GTR18958839HTH (Phospho-S40) Blocking peptide
GTR19103765-01Recombinant Uncharacterized HTH-type transcriptional regulator Mb1846 (Mb1846)
GTR19100538-01Recombinant Rhizobium sp. Uncharacterized HTH-type transcriptional regulator y4fK (NGR_a03710)

Alternative Products

CatalogName
BA6211-100HTHQ
A16335-100HTHQ 100mg
A16335-50HTHQ 50mg
A16335-25HTHQ 25mg
A16335-10HTHQ 10mg
HY-100768R-01HTHQ (Standard)
A16335-200HTHQ 200mg
A16335-5HTHQ 5mg
A16335-10mM-DHTHQ 10mM * 1mL in DMSO
MBS6056068-011-O-Hexyl-2,3,5-trimethylhydroquinone (HTHQ)

Popular Products