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HTH-01-015

CAT: 0013-GTR19162978-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162978-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HTH-01-015 is a potent, specific NUAK1 (AMPK-related kinase 5, ARK5) inhibitor with IC50 of 100 nM, displays >100-fold higher potency than NUAK2; also does not markedly suppress the activity of any of the other 139 protein kinases, including AMPK; suppresses NUAK1-mediated MYPT1 phosphorylation in vivo, the NUAK1 mutation (A195T) renders resistant to HTH-01-015; significantly inhibits migration the proliferation of MEFs (mouse embryonic fibroblasts) .
CAS Number
1613724-42-7
Product Name Alternative
HTH 01 015
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC1=C (N (C) C (C2=CC (C=CC=C3) =C3C=C2N4C) =O) C4=NC (NC5=CN (N=C5) C6CCNCC6) =N1
Molecular Formula
C26H28N8O
Molecular Weight
468.5535
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6H-Naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one, 5,13-dihydro-4,5,13-trimethyl-2-[[1- (4-piperidinyl) -1H-pyrazol-4-yl]amino]-

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A8890-200HTH-01-015
5622/50HTH 01-015

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