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Cimifugin

CAT: 0013-GTR19159532-03Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159532-03Size:500 mg
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Description
Cimifugin inhibits NO production induced by lipopolysaccharide in macrophage cell line RAW 264.7 and for 1, 1-diphenyl-2-picrylhydrazyl free-radical scavenging activity in cell-free bioassay system. (In Vitro) :The effect of Cimifugin (Cimitin) on TSLP decreases significantly when expression of CLDN1 is interfered with siRNA and this implied Cimifugin inhibits initiative cytokines through restoring TJs. (In Vivo) :Cimifugin (Cimitin; 12.5 or 50 mg/kg/day; intragastrically; 2 days) significantly inhibits TSLP and IL-33 in the initial stage of Mice are sensitized and challenged with FITC to establish type 2 atopic dermatitis (AD) model. Simultaneously, Cimifugin reduces the separated gap among the epithelial cells and increased the expression of TJs.
CAS Number
37921-38-3
Product Name Alternative
Cimitin
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 3.1 mg/mL; 10.12 mM
Smiles
CC (C) ([C@@H]1Cc2c (O1) cc1c (c2OC) c (=O) cc (o1) CO) O
Molecular Formula
C16H18O6
Molecular Weight
306.3
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Cimifugin

Cimifugin is an organic heterotricyclic compound and an oxacycle.

CAS Number37921-38-3
PubChem CID441960
IUPAC Name(2S)-7-(hydroxymethyl)-2-(2-hydroxypropan-2-yl)-4-methoxy-2,3-dihydrofuro[3,2-g]chromen-5-one
Molecular FormulaC16H18O6
Molecular Weight306.31
XLogP0.6
Topological Polar Surface Area85.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count22
Formal Charge0
Complexity485
SMILES
CC(C)([C@@H]1CC2=C(O1)C=C3C(=C2OC)C(=O)C=C(O3)CO)O
InChI
InChI=1S/C16H18O6/c1-16(2,19)13-5-9-11(22-13)6-12-14(15(9)20-3)10(18)4-8(7-17)21-12/h4,6,13,17,19H,5,7H2,1-3H3/t13-/m0/s1
InChIKey
ATDBDSBKYKMRGZ-ZDUSSCGKSA-N
Chemical Structure
2D Structure
2D structure of Cimifugin
CAS: 37921-38-3
CID: 441960
Formula: C16H18O6
MW: 306.31
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight306.31
XLogP30.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass306.11033829
Monoisotopic Mass306.11033829
Topological Polar Surface Area85.2 Ų
Heavy Atom Count22
Formal Charge0
Complexity485
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T3383-01Cimifugin
HY-N0634R-01Cimifugin (Standard)
300076Cimifugin discontinued. See 269510
MBS3609125-01Cimifugin beta-D-glucopyranoside
TN1496Cimifugin 4'-O-β-D-glucopyranoside
371282Cimifugin 4'-O-β-D-glucopyranoside discontinued
MC74555-01Cimifugin 4'-O-b-D-glucopyranoside

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