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Briciclib

CAT: 0013-GTR19159325-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19159325-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Briciclib is a small molecule that suppresses cyclin D1 accumulation in Y cells. (In Vitro) :Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI50s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours.
CAS Number
865783-99-9
Product Name Alternative
ON 014185
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 31 mg/mL; 65.34 mM
Smiles
C1 (cc (c (c (c1) OC) /C=C/S (=O) (=O) Cc1ccc (c (c1) OP (=O) (O) O) OC) OC) OC
Molecular Formula
C19H23O10PS
Molecular Weight
474.42
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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