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Briciclib

CAT: 0013-GTR19159325-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19159325-01Size:1 g
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Description
Briciclib is a small molecule that suppresses cyclin D1 accumulation in Y cells. (In Vitro) :Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI50s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours.
CAS Number
865783-99-9
Product Name Alternative
ON 014185
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 31 mg/mL; 65.34 mM
Smiles
C1 (cc (c (c (c1) OC) /C=C/S (=O) (=O) Cc1ccc (c (c1) OP (=O) (O) O) OC) OC) OC
Molecular Formula
C19H23O10PS
Molecular Weight
474.42
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Briciclib

Briciclib has been used in trials studying the treatment of Lymphoma, Neoplasms, Advanced Solid Tumor, and Acute Lymphocytic Leukemia.

CAS Number865783-99-9
PubChem CID11248490
IUPAC Name[2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]phenyl] dihydrogen phosphate
Molecular FormulaC19H23O10PS
Molecular Weight474.4
XLogP1.3
Topological Polar Surface Area146
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count10
Heavy Atom Count31
Formal Charge0
Complexity716
SMILES
COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)OP(=O)(O)O
InChI
InChI=1S/C19H23O10PS/c1-25-14-10-17(27-3)15(18(11-14)28-4)7-8-31(23,24)12-13-5-6-16(26-2)19(9-13)29-30(20,21)22/h5-11H,12H2,1-4H3,(H2,20,21,22)/b8-7+
InChIKey
LXENKEWVEVKKGV-BQYQJAHWSA-N
Chemical Structure
2D Structure
2D structure of Briciclib
CAS: 865783-99-9
CID: 11248490
Formula: C19H23O10PS
MW: 474.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight474.4
XLogP31.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count10
Exact Mass474.07495510
Monoisotopic Mass474.07495510
Topological Polar Surface Area146 Ų
Heavy Atom Count31
Formal Charge0
Complexity716
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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S6533-2mgBriciclib
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