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AG1024

CAT: 0013-GTR19158655-03Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19158655-03Size:1 g
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Description
AG-1024 is also called Tyrphostin, is a selective inhibitor of IGF-1R. AG-1024 was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. Exposure to Tyrphostin AG 1024 inhibited proliferation and induced apoptosis in a time-dependent manner, and the degree of growth inhibition for IC20 plus irradiation (4 Gy) was up to 50% compared to the control. Tyrphostin AG 1024 could be used as a potential therapeutic agent in combination with irradiation.
CAS Number
65678-07-1
Product Name Alternative
AG1024 | AG-1024 | AG 1024. Tyrphostin
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 50 mg/mL; 163.84 mM
Smiles
CC (C) (C) c1c (c (cc (c1) C=C (C#N) C#N) Br) O
Molecular Formula
C14H13BrN2O
Molecular Weight
305.17
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (3-bromo-5-tert-butyl-4-hydroxybenzylidene) malononitrile

Chemical Information

Tyrphostin AG 1024

2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile is an alkylbenzene.

CAS Number65678-07-1
PubChem CID2044
IUPAC Name2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile
Molecular FormulaC14H13BrN2O
Molecular Weight305.17
XLogP4
Topological Polar Surface Area67.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count18
Formal Charge0
Complexity414
SMILES
CC(C)(C)C1=C(C(=CC(=C1)C=C(C#N)C#N)Br)O
InChI
InChI=1S/C14H13BrN2O/c1-14(2,3)11-5-9(4-10(7-16)8-17)6-12(15)13(11)18/h4-6,18H,1-3H3
InChIKey
ABBADGFSRBWENF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Tyrphostin AG 1024
CAS: 65678-07-1
CID: 2044
Formula: C14H13BrN2O
MW: 305.17
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight305.17
XLogP34
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass304.02113
Monoisotopic Mass304.02113
Topological Polar Surface Area67.8 Ų
Heavy Atom Count18
Formal Charge0
Complexity414
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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