MOUSE ANTI HUMAN CD11c:FITC

• Gene Name:

  [CD11c]

• NCBI Gene ID:

  3687

• Reactivity:

  Cynomolgus monkey; N.B. Antibody reactivity and working conditions may vary between species.

• Storage Conditions:

  Store at +4°C or at -20°C if preferred.
  This product should be stored undiluted.
  Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.
  Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

• Specificity:

  Mouse anti Human CD11c antibody, clone Bu15 recognizes the integrin alphax subunit (ITGAX), a ~150 kDa glycoprotein also known as CD11 antigen-like family member C or Leu M5, CD11c is expressed by macrophages, monocytes, NK cells and most dendritic cells (Kohrgruber et al. 1999). CD11c is also expressed at a lower level by granulocytes.
  CD11c forms a heterodimeric integral membrane protein with the integrin beta 2 chain to form the leukocyte specific integrin 'inactivated-C3b receptor 4'. CD11c interacts with a number of ligands including the G-P-R sequence in fibrinogen, ICAM-1 (Frick et al. 2005), iC3b (Sadhu et al. 2007) and Junctional adhesion molecule-like (Bazzoni et al. 2011). CD11c is involved in cell-cell interactions during the inflammatory process and is important for monocyte adhesion and chemotaxis. CD11c also acts as a signalling receptor for polysaccharide (Inqualls et al. 1995)
  CD11c is expressed by hairy cell leukaemia cells (Goodman et al. 2003; Nicolaou et al. 2003).

• Other Gene Names:

  [ITGAX; ITGAX; CD11C; SLEB6; CD11C]

• Short Name:

  [CD11c]

• Other Product Names:

  [integrin alpha-X isoform 2; Integrin alpha-X; integrin alpha-X; CD11 antigen-like family member C; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); leu M5, alpha subunit; leukocyte adhesion glycoprotein p150,95 alpha chain; leukocyte adhesion receptor p150,95; leukocyte surface antigen p150,95, alpha subunit; myeloid membrane antigen, alpha subunit; p150 95 integrin alpha chain; integrin, alpha X (complement component 3 receptor 4 subunit); CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD_antigen: CD11c]

• NCBI GI Number:

  34452173

• NCBI Accession Number:

  NP_000878.2

• NCBI GB Accession Number:

  NM_000887.4

• Uniprot Accession Number:

  P20702

• CAS Number:

  9007-83-4