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DORA-22

CAT: 0013-GTR19157829-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157829-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memoryDORA-22, a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory.DORA-22 treatment improved the insomnia-related sleep disruption-wake was attenuated and NREM sleep was normalized. REM sleep amounts were enhanced compared with vehicle treatment for one dose (30 mg/kg) . In the first hour of insomnia model exposure, DORA-22 promoted the number and average duration of NREM sleep spindles, which have been previously proposed to play a role in memory consolidation (all doses) . Water maze measures revealed probe trial performance improvement for select doses of DORA-22, including increased time spent in the platform quadrant (10 and 30 mg/kg) and time spent in platform location and number of platform crossings (10 mg/kg only) . In conclusion, DORA-22 treatment improved insomnia-related sleep disruption and memory consolidation deficits.
CAS Number
1088991-95-0
Purity
>98% (HPLC)
Smiles
C[C@@H]1CC[C@@H] (COc2ccc (F) cn2) CN1C (=O) c1cc (F) ccc1-c1ncccn1
Molecular Formula
C23H22F2N4O2?
Molecular Weight
424.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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