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Argireline

CAT: 0013-GTR19157632-06Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157632-06Size:50 mg
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Description
Argireline (Acetyl hexapeptide-3) is composed of chains of amino acids known as peptides. Argireline significantly inhibits Ca2+ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline has antiwrinkle and anti-aging activity.The incubation of Argireline solution in different concentrations with human embryonic kidney HEK-293 (IC50 of 34.862 μM) and neuroblastoma IMR-32 cells (IC50 of 68.458 μM) ) for 48 h have dose dependent antiproliferative effect. Argireline solution incubated in different concentrations with HSF has a dose-dependent antiproliferative effect on those cells. Cellular proliferation is not effected in Argireline low concentration.Argireline is applied to the aged mice twice daily for 6 weeks. There is an improvement in the histological structure of skin tissue in the aged mice; the amount of type I collagen fibers increased, while that of type III collagen fibers decreased. Argireline could improve the histological structure of skin tissue and rejuvenate the aging skin.
CAS Number
616204-22-9
Product Name Alternative
Acetyl hexapeptide-3
Purity
>98% (HPLC)
Solubility
H2O:8.8 mg/mL (9.90 mM; Need ultrasonic and warming)
Smiles
CC (=O) N[C@@H] (CCC (=O) O) C (=C) N[C@@H] (CCC (=O) O) C (=O) N[C@@H] (CCSC) C (=O) N[C@@H] (CCC (=O) N) C (=O) N[C@@H] (CCCNC (=N) N) C (=O) N[C@@H] (CCCNC (=N) N) C (=O) N
Molecular Formula
C34H60N14O12S
Molecular Weight
888.99
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Acetyl hexapeptide-3

Argireline has been used in trials studying the treatment of wrinkles.

CAS Number616204-22-9
PubChem CID71587772
IUPAC Name(4S)-4-acetamido-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]hex-5-enoic acid
Molecular FormulaC35H62N14O11S
Molecular Weight887.0
XLogP-5.2
Topological Polar Surface Area472
Hydrogen Bond Donor Count14
Hydrogen Bond Acceptor Count15
Rotatable Bond Count33
Heavy Atom Count61
Formal Charge0
Complexity1610
SMILES
CC(=O)N[C@@H](CCC(=O)O)C(=C)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N
InChI
InChI=1S/C35H62N14O11S/c1-18(20(45-19(2)50)9-12-27(52)53)44-23(10-13-28(54)55)31(58)49-25(14-17-61-3)33(60)48-24(8-11-26(36)51)32(59)47-22(7-5-16-43-35(40)41)30(57)46-21(29(37)56)6-4-15-42-34(38)39/h20-25,44H,1,4-17H2,2-3H3,(H2,36,51)(H2,37,56)(H,45,50)(H,46,57)(H,47,59)(H,48,60)(H,49,58)(H,52,53)(H,54,55)(H4,38,39,42)(H4,40,41,43)/t20-,21-,22-,23-,24-,25-/m0/s1
InChIKey
AJLNZWYOJAWBCR-OOPVGHQCSA-N
Chemical Structure
2D Structure
2D structure of Acetyl hexapeptide-3
CAS: 616204-22-9
CID: 71587772
Formula: C35H62N14O11S
MW: 887.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight887.0
XLogP3-5.2
Hydrogen Bond Donor Count14
Hydrogen Bond Acceptor Count15
Rotatable Bond Count33
Exact Mass886.44432002
Monoisotopic Mass886.44432002
Topological Polar Surface Area472 Ų
Heavy Atom Count61
Formal Charge0
Complexity1610
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
M22308-01Argireline
A22764-100Argireline 100mg
A22764-50Argireline 50mg
FA138103-01Argireline acetate
HY-P0033AArgireline (acetate)
A22764-5Argireline 5mg
A22764-10Argireline 10mg
CSB-DT1690Argireline/Acetyl Hexapeptide-6
O003-100Argireline / DNSP-11 CAS: 616204-22-9

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