MOUSE ANTI SYK

CAT: 0544-MBS212754-01Size: 0.1 mgDry Ice: NoHazardous: No

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CAT#:0544-MBS212754-01Size:0.1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

9007-83-4

Gene Name

[SYK]

NCBI Gene ID

6850

Reactivity

Mouse, Rat

Storage Conditions

Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody.
Shelf Life: 18 months from date of despatch.

Specificity

This item recognizes protein tyrosine kinase p72syk (syk), a 72kDa non-receptor tyrosine kinase, critical for immunoreceptor signaling in haematopoietic cells, but also expressed by nonhaematopoietic cells, including fibroblasts, endothelial cells and hepatocytes.

Syk plays an important role in mast cell response, initiated by the aggregation of the IgE high affinity receptor Fc epsilon R1. Phosphorylation of ITAMs within Fc receptor R1 by another tyrosine kinase lyn, results in the recruitment of syk, which is then responsible for the further phosphorylation of numerous target proteins within many different signal transduction pathways.

Further studies have shown that syk also plays a major role in B cell receptor-mediated apoptosis, proliferation and haematopoiesis. Syk is also reported to associate with protein kinase C alpha during platelet activation.

Other Gene Names

[SYK; SYK; p72-Syk]

Short Name

[SYK]

Other Product Names

[tyrosine-protein kinase SYK isoform Syk(S); Tyrosine-protein kinase SYK; tyrosine-protein kinase SYK; spleen tyrosine kinase; Spleen tyrosine kinase; p72-Syk]

NCBI GI Number

205277435

NCBI Accession Number

NP_001128524.1

NCBI GB Accession Number

NM_001135052.3

Uniprot Accession Number

P43405

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