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Levomefolic Acid

CAT: 0013-GTR19157349-04Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19157349-04Size:1 g
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Description
Levomefolinic acid is a natural active form of folic acid used at the cellular level for DNA reproduction the cysteine cycle and the regulation of homocysteine among other functions. Levomefolinic acid is used as a treatment and to prevent Folate Deficiency. (In Vitro) :Levomefolic acid (5-MTHF) shows interaction with residues Glu406, Ile 418, Lys417 and Tyr453, of which Lys 417 and Tyr 453 play a strong physiological role in the interaction between S1 and ACE and may act as a potential inhibitor of the S1:ACE2 interaction of the SARS-CoV-2 virus.Levomefolic acid (5-MTHF) (50 nM, 72 h) increases intracellular folate metabolite activity by 7-fold better than folic acid by 2-fold in human lymphoblastoid cell line (LCL), and is a good folic acid supplement.
CAS Number
31690-09-2
Product Name Alternative
5-MTHF
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
H2O:5 mg/mL (10.88 mM) ; DMSO:0.526 mg/mL (1.14 mM)
Smiles
CN1[C@@H] (CNc2ccc (cc2) C (=O) N[C@@H] (CCC (O) =O) C (O) =O) CNc2nc (N) [nH]c (=O) c12
Molecular Formula
C20H25N7O6
Molecular Weight
459.46
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(4- ((((S) -2-amino-5-methyl-4-oxo-145678-hexahydropteridin-6-yl) methyl) amino) benzoyl) -L-glutamic acid

Chemical Information

L-Methylfolate

5-methyltetrahydrofolic acid is a tetrahydrofolic acid that is 5,6,7,8-tetrahydrofolic acid substituted by a methyl group at position 5. It has a role as a human metabolite. It is functionally related to a 5,6,7,8-tetrahydrofolic acid. It is a conjugate acid of a 5-methyltetrahydrofolate(2-).

CAS Number31690-09-2
PubChem CID135398561
IUPAC Name(2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioic acid
Molecular FormulaC20H25N7O6
Molecular Weight459.5
XLogP-0.5
Topological Polar Surface Area198
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count10
Rotatable Bond Count9
Heavy Atom Count33
Formal Charge0
Complexity865
SMILES
CN1[C@H](CNC2=C1C(=O)NC(=N2)N)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
InChI
InChI=1S/C20H25N7O6/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29/h2-5,12-13,22H,6-9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H4,21,23,25,26,31)/t12-,13-/m0/s1
InChIKey
ZNOVTXRBGFNYRX-STQMWFEESA-N
Chemical Structure
2D Structure
2D structure of L-Methylfolate
CAS: 31690-09-2
CID: 135398561
Formula: C20H25N7O6
MW: 459.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight459.5
XLogP3-0.5
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count10
Rotatable Bond Count9
Exact Mass459.18663154
Monoisotopic Mass459.18663154
Topological Polar Surface Area198 Ų
Heavy Atom Count33
Formal Charge0
Complexity865
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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