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FG 7142

CAT: 0013-GTR19156976-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19156976-01Size:1 g
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Description
FG 7142 also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM) . FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex. FG 7142 , a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM) . FG-7142 has a high efficacy in modulating GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50 = 137 nM) as compared to the other α subunits.FG-7142 has affinity for those expressing the α subunit, the Ki values are 91 nM; 330 nM; 492 nM and 2.150 μM for α1, α2, α3 and α5 subunits, respectively. FG-7142 (intraperitoneal injection; 15 mg/kg) increases tyrosine hydroxylase activity and dopamine turnover in the medial prefrontal cortex and ventral tegmentum in vivo, but effects are not detected in mesolimbic or nigrostriatal areas.FG-7142 (intraperitoneal injection; 15-30 mg/kg) activates mesolimbocortical dopaminergic projections, leading to increases in dopamine in the prefrontal cortex and the nucleus accumbens in rats.
CAS Number
78538-74-6
Product Name Alternative
ZK 39106, LSU-65
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (443.95 mM)
Smiles
CNC (=O) c1cc2c (cn1) [nH]c1ccccc21
Molecular Formula
C13H11N3O
Molecular Weight
225.25
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

FG-7142

N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide is a member of beta-carbolines.

CAS Number78538-74-6
PubChem CID4375
IUPAC NameN-methyl-9H-pyrido[3,4-b]indole-3-carboxamide
Molecular FormulaC13H11N3O
Molecular Weight225.25
XLogP2.8
Topological Polar Surface Area57.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count17
Formal Charge0
Complexity307
SMILES
CNC(=O)C1=NC=C2C(=C1)C3=CC=CC=C3N2
InChI
InChI=1S/C13H11N3O/c1-14-13(17)11-6-9-8-4-2-3-5-10(8)16-12(9)7-15-11/h2-7,16H,1H3,(H,14,17)
InChIKey
QMCOPDWHWYSJSA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of FG-7142
CAS: 78538-74-6
CID: 4375
Formula: C13H11N3O
MW: 225.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight225.25
XLogP32.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass225.090211983
Monoisotopic Mass225.090211983
Topological Polar Surface Area57.8 Ų
Heavy Atom Count17
Formal Charge0
Complexity307
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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