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6-Methoxyluteolin

CAT: 0013-GTR19156873-02Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156873-02Size:200 mg
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Description
6-Methoxyluteolin has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain.Using the human basophilic KU812F cells, we assessed the inhibitory effects of 6-Methoxyluteolin, isolated from Chrysanthemum zawadskii, in the FcαμRI-mediated allergic reaction. We determined that 6-Methoxyluteolin inhibited anti-FcαμRI α± chain antibody (CRA-1) -induced histamine release, as well as elevation of intracellular calcium concentration [Ca2+]i in a dose-dependent manner. Moreover, the inhibitory effects of 6-Methoxyluteolin on the cell surface expression and the mRNA level of the FcαμRI α± chain were determined by flow cytometric analysis and reverse transcription-polymerase chain reaction (RTPCR), respectively.
CAS Number
520-11-6
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 125 mg/mL (395.24 mM)
Smiles
COc1c (O) cc2oc (cc (=O) c2c1O) -c1ccc (O) c (O) c1
Molecular Formula
C16H12O7
Molecular Weight
316.26
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Nepetin

nepetin has been reported in Salvia plebeia, Coreopsis lanceolata, and other organisms with data available.

CAS Number520-11-6
PubChem CID5317284
IUPAC Name2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one
Molecular FormulaC16H12O7
Molecular Weight316.26
XLogP1.4
Topological Polar Surface Area116
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Heavy Atom Count23
Formal Charge0
Complexity491
SMILES
COC1=C(C2=C(C=C1O)OC(=CC2=O)C3=CC(=C(C=C3)O)O)O
InChI
InChI=1S/C16H12O7/c1-22-16-11(20)6-13-14(15(16)21)10(19)5-12(23-13)7-2-3-8(17)9(18)4-7/h2-6,17-18,20-21H,1H3
InChIKey
FHHSEFRSDKWJKJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Nepetin
CAS: 520-11-6
CID: 5317284
Formula: C16H12O7
MW: 316.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight316.26
XLogP31.4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass316.05830272
Monoisotopic Mass316.05830272
Topological Polar Surface Area116 Ų
Heavy Atom Count23
Formal Charge0
Complexity491
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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