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Calcimycin

CAT: 0013-GTR19156858-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156858-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Calcimycin is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis. It binds and transports calcium and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems. Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner.Calcimycin (2.5 or 7.5 nM; intrapleurally) induces protein leakage.
CAS Number
52665-69-7
Product Name Alternative
A-23187, Antibiotic A-23187
Purity
>98% (HPLC)
Solubility
DMSO:47 mg/mL (89.76mM; Need ultrasonic)
Smiles
[H][C@@]1 (O[C@@]2 (CC[C@@H] (C) [C@@H] (Cc3nc4c (C (O) =O) c (NC) ccc4o3) O2) [C@H] (C) C[C@H]1C) [C@H] (C) C (=O) c1ccc[nH]1
Molecular Formula
C29H37N3O6
Molecular Weight
523.62
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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C160-1MGCalcimycin
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HY-N6687RCalcimycin (Standard)
CST 23911SA23187 (Calcimycin)
BIC1006-01Calcimycin A23187
HY-N6687A-01Calcimycin (hemicalcium salt)
HY-N6687CCalcimycin (hemicalcium hemimagnesium)
BML-CA100-0010Antibiotic A-23187 (Calcimycin)
MBS5766260Calcimycin hemicalcium salt

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