CU-T12-9

CAT: 0013-GTR19156615-01Size: 1 gDry Ice: NoHazardous: No

1 / 1

CAT#:0013-GTR19156615-01Size:1 g

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

CU-T12-9 is a potent TLR1/2 agonist (EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay) . It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS.CU-T12-9 directly targets TLR1/2 to initiate downstream signaling. CU-T12-9 specifically induces TLR1/2 activation, which can be blocked by either the anti-hTLR1 or the anti-hTLR2 antibody, but not the anti-hTLR6 antibody. By binding to both TLR1 and TLR2, CU-T12-9 facilitates the TLR1/2 heterodimeric complex formation, which in turn activates the downstream signaling. Fluorescence anisotropy assays revealed competitive binding to the TLR1/2 complex between CU-T12-9 and Pam3CSK4 with a half-maximal inhibitory concentration (IC50) of 54.4 nM. CU-T12-9 signals through nuclear factor κB (NF-κB) and invokes an elevation of the downstream effectors tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), and inducible nitric oxide synthase (iNOS) .

CAS Number

1821387-73-8

Purity

>98% (HPLC)

Solubility

DMSO:250 mg/mL (690.02 mM; Need ultrasonic)

Smiles

CNC1=CC=C (C=C1N2C=C (N=C2) C3=CC=C (C=C3) C (F) (F) F) [N+] ([O-]) =O

Molecular Formula

C17H13F3N4O2

Molecular Weight

362.31

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Related Products

Catalog	Name
GTR19029893	TfR-T12
GTR18919122-01	TfR-T12 acetate
GTR19062138-01	TfR-T12 TFA
GTR18328205-01	Phospho-LC3B (T12) Antibody
GTR19230771-01	SA09-Cu
GTR19192177-01	CU-CPD107
GTR19251490-01	CU-CPT8m
GTR19157479-01	CU-CPT22
GTR19197827-01	CU-3
GTR19189999-01	CU-32

Alternative Products

Catalog	Name
T15017-01	CU-T12-9
A24317-5	CU-T12-9 5mg
A24317-1	CU-T12-9 1mg
A24317-50	CU-T12-9 50mg
A24317-10	CU-T12-9 10mg

CU-T12-9

Related Products

Alternative Products

Popular Products