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Hoechst 34580

CAT: 0013-GTR19156604-02Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156604-02Size:500 mg
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Description
Hoechst 34580, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.Hoechst 34580 is a good candidate for treating Alzheimer’s disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner. The IC50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86±0.05 μM for Hoechst 34580.
CAS Number
23555-00-2
Product Name Alternative
HOE 34580
Purity
>98% (HPLC)
Solubility
DMSO:47 mg/mL (104.08 mM)
Smiles
CN1CCN (C2=CC=C3C (N=C (C4=CC=C5C (N=C (C6=CC=C (N (C) C) C=C6) N5) =C4) N3) =C2) CC1
Molecular Formula
C27H29N7
Molecular Weight
451.57
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Hoechst 34580

structure in first source

CAS Number23555-00-2
PubChem CID448202
IUPAC NameN,N-dimethyl-4-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]aniline
Molecular FormulaC27H29N7
Molecular Weight451.6
XLogP4.4
Topological Polar Surface Area67.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count34
Formal Charge0
Complexity672
SMILES
CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=CC5=C(C=C4)N=C(N5)C6=CC=C(C=C6)N(C)C
InChI
InChI=1S/C27H29N7/c1-32(2)20-7-4-18(5-8-20)26-28-22-10-6-19(16-24(22)30-26)27-29-23-11-9-21(17-25(23)31-27)34-14-12-33(3)13-15-34/h4-11,16-17H,12-15H2,1-3H3,(H,28,30)(H,29,31)
InChIKey
VMCOQLKKSNQANE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Hoechst 34580
CAS: 23555-00-2
CID: 448202
Formula: C27H29N7
MW: 451.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight451.6
XLogP34.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass451.24844395
Monoisotopic Mass451.24844395
Topological Polar Surface Area67.1 Ų
Heavy Atom Count34
Formal Charge0
Complexity672
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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