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HALOFUGINONE LACTATE

CAT: 0013-GTR19156560-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19156560-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activityhalofuginone (HF), a widely studied derivative of febrifugine, inhibits the development of T (H) 17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway. HF binds glutamyl-prolyl-tRNA synthetase (EPRS), inhibiting prolyl-tRNA synthetase activity; this inhibition is reversed by the addition of exogenous proline or EPRS.
CAS Number
82186-71-8
Purity
>98% (HPLC)
Smiles
CC (O) C (O) =O.O=C1N (CC (C[C@@H]2NCCC[C@H]2O) =O) C=NC3=C1C=C (Cl) C (Br) =C3
Molecular Formula
C19H23BrClN3O6
Molecular Weight
504.8
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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