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PF 6274484

CAT: 0013-GTR19156516-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19156516-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF 6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively.
CAS Number
1035638-91-5
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 25 mg/mL (67.06 mM)
Smiles
COc (cc (c1c2) ncnc1Nc (cc1) cc (Cl) c1F) c2NC (C=C) =O
Molecular Formula
C18H14ClFN4O2
Molecular Weight
372.8
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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