Products for Research Use Only
RegisterLogin

PF-5274857 freebase

CAT: 0013-GTR19156205-01Size: 200 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19156205-01Size:200 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PF-5274857 is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM) . PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.PF-5274857 was found to effectively penetrate the blood-brain barrier and inhibit Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates. PF-5274857 was orally available and metabolically stable in vivo.
CAS Number
1373615-35-0
Product Name Alternative
PF-5274857 | PF 5274857 | PF5274857
Purity
>98% (HPLC)
Solubility
DMSO:125 mg/mL (286.07 mM; Need ultrasonic)
Smiles
CC1=CC (=C (N=C1) C2=CC (=NC=C2Cl) N3CCN (CC3) C (=O) CCS (=O) (=O) C) C
Molecular Formula
C20H25ClN4O3S
Molecular Weight
436.96
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Related Products

CatalogName
GTR19169708-01PF-5274857
GTR19192045PF-5274857 hydrochloride
GTR19224311-01PF-5274857 mseylate (1373615-35-0 free base)
GTR19224314-01PF-06745013
GTR19222974-01PF-06764427
GTR19218956-01PF-07208254
GTR19218556-01PF-07059013
GTR19213053-01PF-17
GTR19212475-01PF-06455943
GTR19211449-01PF-446687

Alternative Products

CatalogName
M23528-01PF-5274857 freebase
T5465-01PF-5274857
FP143186-01PF 5274857
T35563PF-5274857 hydrochloride
A12775-10PF-5274857 10mg
FP143187-01PF 5274857 hydrochloride
563691PF-5274857 HCl
A12775-100PF-5274857 100mg
A12775-25PF-5274857 25mg
HY-13459APF-5274857 (hydrochloride)

Popular Products