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INT-131

CAT: 0013-GTR19155319-06Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19155319-06Size:25 mg
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Description
INT-131, is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR) gamma modulator, which can be used for the treatment of type 2 diabetes mellitus (non-insulin dependent diabetes) (In Vitro) :AMG131 (INT131) binds to PPARγ and displaces Rosiglitazone with a Ki of ~10 nM, demonstrating ~20-fold higher affinity than either Rosiglitazone or Pioglitazone, and with greater than 1000-fold selectivity for PPARγ over PPARα, PPARδ, or a set of other nuclear receptors. AMG131 is highly selective for PPARγ, with no binding to PPARα or δ at 10 μM, 1000 fold over the Ki for PPARγ. (In Vivo) :AMG131 (INT131; 80 mg/kg; 14-day oral treatment) increases in glucose tolerance in Zucker (fa/fa) rats following.
CAS Number
315224-26-1
Product Name Alternative
AMG-131 | CHS 131
Field of Research
Stem Cell & Developmental Biology
Purity
>98% (HPLC)
Solubility
DMSO:10 mM
Smiles
C1=CC=C2C (=C1) C=C (C=N2) OC3=C (C=C (C=C3Cl) NS (=O) (=O) C4=C (C=C (C=C4) Cl) Cl) Cl
Molecular Formula
C21H12Cl4N2O3S
Molecular Weight
514.21
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Amg-131

AMG-131 (T131), an orally-administered therapy, is expected to lower blood glucose in type II diabetic patients by improving the body’s ability to respond to insulin. T131 is a selective modulator of PPARg (peroxisome proliferator activated receptor gamma), a receptor involved in regulating the body’s ability to respond to insulin. T131 is not structurally related to the thiazolidinedione class of PPARg agonists, which includes Actos and Avandia.

CAS Number315224-26-1
PubChem CID10229498
IUPAC Name2,4-dichloro-N-(3,5-dichloro-4-quinolin-3-yloxyphenyl)benzenesulfonamide
Molecular FormulaC21H12Cl4N2O3S
Molecular Weight514.2
XLogP6.8
Topological Polar Surface Area76.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count31
Formal Charge0
Complexity697
SMILES
C1=CC=C2C(=C1)C=C(C=N2)OC3=C(C=C(C=C3Cl)NS(=O)(=O)C4=C(C=C(C=C4)Cl)Cl)Cl
InChI
InChI=1S/C21H12Cl4N2O3S/c22-13-5-6-20(16(23)8-13)31(28,29)27-14-9-17(24)21(18(25)10-14)30-15-7-12-3-1-2-4-19(12)26-11-15/h1-11,27H
InChIKey
NMRWDFUZLLQSBN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Amg-131
CAS: 315224-26-1
CID: 10229498
Formula: C21H12Cl4N2O3S
MW: 514.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight514.2
XLogP36.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass513.929324
Monoisotopic Mass511.932274
Topological Polar Surface Area76.7 Ų
Heavy Atom Count31
Formal Charge0
Complexity697
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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