INT-777

CAT: 0013-GTR19205572-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19205572-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

INT-777 (S-EMCA) is a potent TGR5 receptor agonist exhibiting an EC50 of 0.82 μM. It has been shown to suppress neuroinflammation by inhibiting the NLRP3-ASC inflammasome via the TGR5/cAMP/PKA pathway in rat models of subarachnoid hemorrhage, highlighting its utility in neuroscience and inflammation research.

CAS Number

1199796-29-6

Product Name Alternative

INT 777, INT777, INT-777, S-EMCA, TGR5

Field of Research

Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Purity

99.38% (May vary between batches)

Solubility

DMSO:30 mg/mL (66.57 mM) ; Ethanol:50 mg/mL (110.95 mM)

Smiles

[H][C@@]12CC[C@H] ([C@H] (C) C[C@H] (C) C (O) =O) [C@@]1 (C) [C@@H] (O) C[C@@]1 ([H]) [C@@]2 ([H]) [C@H] (O) [C@H] (CC) [C@]2 ([H]) C[C@H] (O) CC[C@]12C

Molecular Formula

C27H46O5

Molecular Weight

450.65

Storage Conditions

-20°C

Notes

For research use only.

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Alternative Products

Catalog	Name
B4672-100	INT-777
A21168-10	INT-777 10mg
A21168-100	INT-777 100mg
A21168-25	INT-777 25mg
A21168-2	INT-777 2mg
A21168-50	INT-777 50mg
A21168-5	INT-777 5mg
A21168-1	INT-777 1mg
HY-15677A-01	INT-777 (R-enantiomer)
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INT-777

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