INT-131

CAT: 0013-GTR19155319-01Size: 200 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0013-GTR19155319-01Size:200 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

INT-131, is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR) gamma modulator, which can be used for the treatment of type 2 diabetes mellitus (non-insulin dependent diabetes) (In Vitro) :AMG131 (INT131) binds to PPARγ and displaces Rosiglitazone with a Ki of ~10 nM, demonstrating ~20-fold higher affinity than either Rosiglitazone or Pioglitazone, and with greater than 1000-fold selectivity for PPARγ over PPARα, PPARδ, or a set of other nuclear receptors. AMG131 is highly selective for PPARγ, with no binding to PPARα or δ at 10 μM, 1000 fold over the Ki for PPARγ. (In Vivo) :AMG131 (INT131; 80 mg/kg; 14-day oral treatment) increases in glucose tolerance in Zucker (fa/fa) rats following.

CAS Number

315224-26-1

Product Name Alternative

AMG-131 | CHS 131

Field of Research

Stem Cell & Developmental Biology

Purity

>98% (HPLC)

Solubility

DMSO:10 mM

Smiles

C1=CC=C2C (=C1) C=C (C=N2) OC3=C (C=C (C=C3Cl) NS (=O) (=O) C4=C (C=C (C=C4) Cl) Cl) Cl

Molecular Formula

C21H12Cl4N2O3S

Molecular Weight

514.21

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Related Products

Catalog	Name
GTR19156099-01	INT
GTR19173030-01	INT
GTR17998269	Int Antibody
GTR19161953-01	INT-747
GTR17998666	Int Antibody
GTR17998665	Int Antibody
GTR19219719-01	INT. 2
GTR19205572-01	INT-777
GTR17998467	Int Antibody
GTR17998267	Int Antibody

Alternative Products

Catalog	Name
QMA22426-01	INT 131
MBS5764962	INT-131
40900004-1	INT
B4672-100	INT-777
BA3629-5	INT-767
21530051-1	BCIP/INT
HY-119984-01	DNP-INT
MBS5825379	INT. 2

INT-131

Related Products

Alternative Products

Popular Products